Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Osteosarcomas, the most common malignant bone tumors, show a potent capacity for local invasion and pulmonary metastasis. Resveratrol (RESV), a phytochemical, exhibits multiple tumor-suppressing activities and has been tested in clinical trials. However, the antitumor activities of RESV in osteosarc...

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Vydáno v:Oncotarget
Hlavní autoři: Yang, Shun-Fa, Lee, Wei-Jiunn, Tan, Peng, Tang, Chih-Hsin, Hsiao, Michael, Hsieh, Feng-Koo, Chien, Ming-Hsien
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413614/
https://ncbi.nlm.nih.gov/pubmed/25605016
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