CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d

Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a secreted protein, binds to integrins, modulates invasive behavior of certain human cancer cells. Effect of CTGF in metastasis of...

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Main Authors: Tsai, Hsiao-Chi, Su, Hong-Lin, Huang, Chun-Yin, Fong, Yi-Chin, Hsu, Chin-Jung, Tang, Chih-Hsin
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116521/
https://ncbi.nlm.nih.gov/pubmed/25003330
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