Bevacizumab modulates retinal pigment epithelial-to-mesenchymal transition via regulating Notch signaling

AIM: To investigate the effect of bevacizumab treatment on Notch signaling and the induction of epithelial-of-mesenchymal transition (EMT) in human retinal pigment epithelial cells (ARPE-19) in vitro. METHODS: In vitro cultivated ARPE-19 cells were treated with 0.25 mg/mL bevacizumab for 12, 24, and...

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Udgivet i:Int J Ophthalmol
Main Authors: Zhang, Jing-Jing, Chu, San-Jun, Sun, Xiao-Lei, Zhang, Ting, Shi, Wei-Yun
Format: Artigo
Sprog:Inglês
Udgivet: International Journal of Ophthalmology Press 2015
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413575/
https://ncbi.nlm.nih.gov/pubmed/25938035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3980/j.issn.2222-3959.2015.02.06
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