Measurement of H(2)O(2) within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Hydrogen peroxide (H(2)O(2)) is central to mitochondrial oxidative damage and redox signaling, but its roles are poorly understood due to the difficulty of measuring mitochondrial H(2)O(2) in vivo. Here we report a ratiometric mass spectrometry probe approach to assess mitochondrial matrix H(2)O(2)...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Cochemé, Helena M., Quin, Caroline, McQuaker, Stephen J., Cabreiro, Filipe, Logan, Angela, Prime, Tracy A., Abakumova, Irina, Patel, Jigna V., Fearnley, Ian M., James, Andrew M., Porteous, Carolyn M., Smith, Robin A.J., Saeed, Saima, Carré, Jane E., Singer, Mervyn, Gems, David, Hartley, Richard C., Partridge, Linda, Murphy, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413513/
https://ncbi.nlm.nih.gov/pubmed/21356523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.02.003
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