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Direct conversion of human myoblasts into brown-like adipocytes by engineered superactive PPARγ
OBJECTIVE: To determine whether super-activation of PPARγ can reprogram human myoblasts into brownlike adipocytes and to establish a new cell model for browning research. METHODS: To enhance the PPARγ signaling, we fused M3, the transactivation domain of MyoD, to PPARγ. PPARγ and M3-PPARγ-lentiviral...
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| Udgivet i: | Obesity (Silver Spring) |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413469/ https://ncbi.nlm.nih.gov/pubmed/25919922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.21062 |
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