Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis

Silencing of interleukin-32 (IL-32) in a differentiated human promonocytic cell line impairs killing of Mycobacterium tuberculosis (MTB) but the role of IL-32 in vivo against MTB remains unknown. To study the effects of IL-32 in vivo, a transgenic mouse was generated in which the human IL-32γ gene i...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bai, Xiyuan, Shang, Shaobin, Henao-Tamayo, Marcela, Basaraba, Randall J., Ovrutsky, Alida R., Matsuda, Jennifer L., Takeda, Katsuyuki, Chan, Mallory M., Dakhama, Azzeddine, Kinney, William H., Trostel, Jessica, Bai, An, Honda, Jennifer R., Achcar, Rosane, Hartney, John, Joosten, Leo A. B., Kim, Soo-Hyun, Orme, Ian, Dinarello, Charles A., Ordway, Diane J., Chan, Edward D.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413346/
https://ncbi.nlm.nih.gov/pubmed/25820174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424302112
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