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Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression
Angelman syndrome (AS) is a neurodevelopmental disorder arising from loss-of-function mutations in the maternally inherited copy of the UBE3A gene, and is characterized by an absence of speech, excessive laughter, cognitive delay, motor deficits, and seizures. Despite the fact that the symptoms of A...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413330/ https://ncbi.nlm.nih.gov/pubmed/25848016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504809112 |
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