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Cadmium–cysteine coordination in the BK inner pore region and its structural and functional implications

To probe structure and gating-associated conformational changes in BK-type potassium (BK) channels, we examined consequences of Cd(2+) coordination with cysteines introduced at two positions in the BK inner pore. At V319C, the equivalent of valine in the conserved Kv proline-valine-proline (PVP) mot...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Zhou, Yu, Xia, Xiao-Ming, Lingle, Christopher J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413310/
https://ncbi.nlm.nih.gov/pubmed/25848005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500953112
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