Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits

Alzheimer’s disease (AD) is one of most devastating diseases affecting elderly people. Amyloid-β (Aβ) accumulation and the downstream pathological events such as oxidative stress play critical roles in pathogenesis of AD. Lessons from failures of current clinical trials suggest that targeting multip...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Jiao, Shu-Sheng, Yao, Xiu-Qing, Liu, Yu-Hui, Wang, Qing-Hua, Zeng, Fan, Lu, Jian-Jun, Liu, Jia, Zhu, Chi, Shen, Lin-Lin, Liu, Cheng-Hui, Wang, Ye-Ran, Zeng, Gui-Hua, Parikh, Ankit, Chen, Jia, Liang, Chun-Rong, Xiang, Yang, Bu, Xian-Le, Deng, Juan, Li, Jing, Xu, Juan, Zeng, Yue-Qin, Xu, Xiang, Xu, Hai-Wei, Zhong, Jin-Hua, Zhou, Hua-Dong, Zhou, Xin-Fu, Wang, Yan-Jiang
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413288/
https://ncbi.nlm.nih.gov/pubmed/25847999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422998112
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