Mutation of SH2B3 (LNK), a GWAS candidate for hypertension, attenuates Dahl SS hypertension via inflammatory modulation

Human genome wide association studies (GWAS) have linked SH2B3 (LNK) to hypertension and renal disease, though little experimental investigation has been done to verify a role for SH2B3 in these pathologies. SH2B3, a member of the SH2B adaptor protein family, is an intracellular adaptor protein that...

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Vydáno v:Hypertension
Hlavní autoři: Rudemiller, Nathan P., Lund, Hayley, Priestley, Jessica R. C., Endres, Bradley T., Prokop, Jeremy W., Jacob, Howard J., Geurts, Aron M., Cohen, Eric P., Mattson, David L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412596/
https://ncbi.nlm.nih.gov/pubmed/25776069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04736
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