Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors

A novel series of N-(3-(6-substituted-aminopyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting TrkA receptor tyrosine kinase was identified. SAR study of the series allowed us to design and synthesize compounds possessing inhibitory activity of TrkA kinase enzyme in the low...

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Bibliographic Details
Published in:Int J Med Chem
Main Authors: Raeppel, Stéphane L., Gaudette, Frédéric, Nguyen, Hannah, Beaulieu, Normand, Wang, James, Maroun, Christiane, Besterman, Jeffrey M., Vaisburg, Arkadii
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412093/
https://ncbi.nlm.nih.gov/pubmed/25954527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/412614
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