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Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

Hematopoietic stem cells (HSCs) are maintained by a perivascular niche in bone marrow but it is unclear whether the niche is reciprocally regulated by HSCs. Here, we systematically assessed the expression and function of Angiopoietin-1 (Angpt1) in bone marrow. Angpt1 was not expressed by osteoblasts...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhou, Bo O, Ding, Lei, Morrison, Sean J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411515/
https://ncbi.nlm.nih.gov/pubmed/25821987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05521
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