Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.

Tumor-specific activation of the TAL1 gene is the most common genetic defect associated with T-cell acute lymphoblastic leukemia. The TAL1 gene products possess a basic helix-loop-helix (bHLH) motif, a protein-dimerization and DNA-binding domain found in several transcription factors. TAL1 polypepti...

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Bibliographic Details
Main Authors: Hsu, H L, Wadman, I, Tsan, J T, Baer, R
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC44114/
https://ncbi.nlm.nih.gov/pubmed/8016094
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