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A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation

The transient receptor potential (TRP) channels act as key sensors of various chemical and physical stimuli in eukaryotic cells. Despite years of study, the molecular mechanisms of TRP channel activation remain unclear. To elucidate the structural, dynamic, and energetic basis of gating in TRPV1 (a...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Zheng, Wenjun, Qin, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411258/
https://ncbi.nlm.nih.gov/pubmed/25918362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411335
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