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Pachymic Acid Inhibits Growth and Induces Apoptosis of Pancreatic Cancer In Vitro and In Vivo by Targeting ER Stress

Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human chemotherapy resistant pancreatic cancer. PA triggered apoptosis in gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2. Compar...

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Vydáno v:PLoS One
Hlavní autoři: Cheng, Shujie, Swanson, Kristen, Eliaz, Isaac, McClintick, Jeanette N., Sandusky, George E., Sliva, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411097/
https://ncbi.nlm.nih.gov/pubmed/25915041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122270
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