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Exploring the Mechanisms of the Reductase Activity of Neuroglobin by Site-Directed Mutagenesis of the Heme Distal Pocket

[Image: see text] Neuroglobin (Ngb) is a six-coordinate globin that can catalyze the reduction of nitrite to nitric oxide. Although this reaction is common to heme proteins, the molecular interactions in the heme pocket that regulate this reaction are largely unknown. We have shown that the H64L Ngb...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Biochemistry
Κύριοι συγγραφείς: Tejero, Jesús, Sparacino-Watkins, Courtney E., Ragireddy, Venkata, Frizzell, Sheila, Gladwin, Mark T.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2015
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410703/
https://ncbi.nlm.nih.gov/pubmed/25554946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501196k
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