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Exploring the Mechanisms of the Reductase Activity of Neuroglobin by Site-Directed Mutagenesis of the Heme Distal Pocket

[Image: see text] Neuroglobin (Ngb) is a six-coordinate globin that can catalyze the reduction of nitrite to nitric oxide. Although this reaction is common to heme proteins, the molecular interactions in the heme pocket that regulate this reaction are largely unknown. We have shown that the H64L Ngb...

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書誌詳細
出版年:Biochemistry
主要な著者: Tejero, Jesús, Sparacino-Watkins, Courtney E., Ragireddy, Venkata, Frizzell, Sheila, Gladwin, Mark T.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2015
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410703/
https://ncbi.nlm.nih.gov/pubmed/25554946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501196k
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