14-3-3 Binding and Phosphorylation of Neuroglobin during Hypoxia Modulate Six-to-Five Heme Pocket Coordination and Rate of Nitrite Reduction to Nitric Oxide

Neuroglobin protects neurons from hypoxia in vitro and in vivo; however, the underlying mechanisms for this effect remain poorly understood. Most of the neuroglobin is present in a hexacoordinate state with proximal and distal histidines in the heme pocket directly bound to the heme iron. At equilib...

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Detalhes bibliográficos
Main Authors: Jayaraman, Thottala, Tejero, Jesús, Chen, Bill B., Blood, Arlin B., Frizzell, Sheila, Shapiro, Calli, Tiso, Mauro, Hood, Brian L., Wang, Xunde, Zhao, Xuejun, Conrads, Thomas P., Mallampalli, Rama K., Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234913/
https://ncbi.nlm.nih.gov/pubmed/21965683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271973
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