Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core.
We have examined the consequences of DNA distortion and specific histone-DNA contacts within the nucleosome for integration mediated by the human immunodeficiency virus (HIV)-encoded integrase enzyme. We find that sites of high-frequency integration cluster in the most severely deformed, kinked DNA...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44107/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8016088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.13.5913 |
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