Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core.

We have examined the consequences of DNA distortion and specific histone-DNA contacts within the nucleosome for integration mediated by the human immunodeficiency virus (HIV)-encoded integrase enzyme. We find that sites of high-frequency integration cluster in the most severely deformed, kinked DNA...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Proc Natl Acad Sci U S A
Päätekijät:	Pruss, D, Bushman, F D, Wolffe, A P
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	National Academy of Sciences 1994
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44107/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8016088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.13.5913
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!