Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core.

We have examined the consequences of DNA distortion and specific histone-DNA contacts within the nucleosome for integration mediated by the human immunodeficiency virus (HIV)-encoded integrase enzyme. We find that sites of high-frequency integration cluster in the most severely deformed, kinked DNA...

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Bibliographic Details
Main Authors: Pruss, D, Bushman, F D, Wolffe, A P
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC44107/
https://ncbi.nlm.nih.gov/pubmed/8016088
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