Promiscuous Actions of Small Molecule Inhibitors of the Protein Kinase D-Class IIa HDAC Axis in Striated Muscle

PKD-mediated phosphorylation of class IIa HDACs frees the MEF2 transcription factor to activate genes that govern muscle differentiation and growth. Studies of the regulation and function of this signaling axis have involved MC1568 and Gö-6976, which are small molecule inhibitors of class IIa HDAC a...

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Bibliografiska uppgifter
I publikationen:FEBS Lett
Huvudupphovsmän: Lemon, Douglas D., Harrison, Brooke C., Horn, Todd R., Stratton, Matthew S., Ferguson, Bradley S., Wempe, Michael F., McKinsey, Timothy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410688/
https://ncbi.nlm.nih.gov/pubmed/25816750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.03.017
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