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Bioreducible Polycations in Nucleic Acid Delivery: Past, Present, and Future Trends

Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This paper surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is plac...

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Publicado en:Macromol Biosci
Autores principales: Oupický, David, Li, Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410047/
https://ncbi.nlm.nih.gov/pubmed/24678057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mabi.201400061
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