Cross-tissue methylomic profiling strongly implicates a role for cortex-specific deregulation of ANK1 in Alzheimer’s disease neuropathology

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive neuropathology and cognitive decline. We describe a cross-tissue analysis of methylomic variation in AD using samples from three independent human post-mortem brain cohorts. We identify a differentially met...

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Vydáno v:Nat Neurosci
Hlavní autoři: Lunnon, Katie, Smith, Rebecca, Hannon, Eilis, De Jager, Philip, Srivastava, Gyan, Volta, Manuela, Troakes, Claire, Al-Sarraj, Safa, Burrage, Joe, Macdonald, Ruby, Condliffe, Daniel, Harries, Lorna W., Katsel, Pavel, Haroutunian, Vahram, Kaminsky, Zachary, Joachim, Catharine, Powell, John, Lovestone, Simon, Bennett, David A., Schalkwyk, Leonard, Mill, Jonathan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410018/
https://ncbi.nlm.nih.gov/pubmed/25129077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3782
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