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Stereoselective Pharmacokinetics of Stable Isotope (+/−)-[(13)C]-Pantoprazole: Implications for a Rapid Screening Phenotype Test of CYP2C19 Activity

AIMS: We have previously shown that the (±)-[(13)C]-pantoprazole breath test is a promising noninvasive probe of CYP2C19 activity. As part of that trial, plasma, breath test indices and CYP2C19 (*2, *3 and *17) genotype were collected. Here, we examined whether [(13)C]-pantoprazole exhibits enantios...

詳細記述

保存先:
書誌詳細
出版年:Chirality
主要な著者: Thacker, David L., Modak, Anil, Nguyen, Phuong D., Flockhart, David A., Desta, Zeruesenay
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409653/
https://ncbi.nlm.nih.gov/pubmed/21935988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chir.21011
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