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Comprehensive In Vitro Analysis of Voriconazole Inhibition of Eight Cytochrome P450 (CYP) Enzymes: Major Effect on CYPs 2B6, 2C9, 2C19, and 3A

Voriconazole is an effective antifungal drug, but adverse drug-drug interactions associated with its use are of major clinical concern. To identify the mechanisms of these interactions, we tested the inhibitory potency of voriconazole with eight human cytochrome P450 (CYP) enzymes. Isoform-specific...

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Autori principali: Jeong, Seongwook, Nguyen, Phuong D., Desta, Zeruesenay
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630638/
https://ncbi.nlm.nih.gov/pubmed/19029318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01123-08
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