Comprehensive In Vitro Analysis of Voriconazole Inhibition of Eight Cytochrome P450 (CYP) Enzymes: Major Effect on CYPs 2B6, 2C9, 2C19, and 3A

Voriconazole is an effective antifungal drug, but adverse drug-drug interactions associated with its use are of major clinical concern. To identify the mechanisms of these interactions, we tested the inhibitory potency of voriconazole with eight human cytochrome P450 (CYP) enzymes. Isoform-specific...

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Hlavní autoři: Jeong, Seongwook, Nguyen, Phuong D., Desta, Zeruesenay
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630638/
https://ncbi.nlm.nih.gov/pubmed/19029318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01123-08
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