Stereoselective Pharmacokinetics of Stable Isotope (+/−)-[(13)C]-Pantoprazole: Implications for a Rapid Screening Phenotype Test of CYP2C19 Activity

AIMS: We have previously shown that the (±)-[(13)C]-pantoprazole breath test is a promising noninvasive probe of CYP2C19 activity. As part of that trial, plasma, breath test indices and CYP2C19 (*2, *3 and *17) genotype were collected. Here, we examined whether [(13)C]-pantoprazole exhibits enantios...

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Bibliographic Details
Published in:Chirality
Main Authors: Thacker, David L., Modak, Anil, Nguyen, Phuong D., Flockhart, David A., Desta, Zeruesenay
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409653/
https://ncbi.nlm.nih.gov/pubmed/21935988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chir.21011
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