The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

Most mammalian transcription factors (TFs) and cofactors occupy thousands of genomic sites and modulate the expression of large gene networks to implement their biological functions. In this study, we describe an exception to this paradigm. TRIM33 is identified here as a lineage dependency in B cell...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wang, Eric, Kawaoka, Shinpei, Roe, Jae-Seok, Shi, Junwei, Hohmann, Anja F, Xu, Yali, Bhagwat, Anand S, Suzuki, Yutaka, Kinney, Justin B, Vakoc, Christopher R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409649/
https://ncbi.nlm.nih.gov/pubmed/25919951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06377
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