The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

Most mammalian transcription factors (TFs) and cofactors occupy thousands of genomic sites and modulate the expression of large gene networks to implement their biological functions. In this study, we describe an exception to this paradigm. TRIM33 is identified here as a lineage dependency in B cell...

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Publicado en:eLife
Autores principales: Wang, Eric, Kawaoka, Shinpei, Roe, Jae-Seok, Shi, Junwei, Hohmann, Anja F, Xu, Yali, Bhagwat, Anand S, Suzuki, Yutaka, Kinney, Justin B, Vakoc, Christopher R
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Genes and Chromosomes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409649/
https://ncbi.nlm.nih.gov/pubmed/25919951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06377
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