Pak2 regulates hematopoietic progenitor cell proliferation, survival and differentiation

p21-activated kinase 2 (Pak2), a serine/threonine kinase, has been previously shown to be essential for hematopoietic stem cell (HSC) engraftment. However, Pak2 modulation of long-term hematopoiesis and lineage commitment remain unreported. Utilizing a conditional Pak2 knock out (KO) mouse model, we...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Zeng, Yi, Broxmeyer, Hal E., Staser, Karl, Chitteti, Brahmananda Reddy, Park, Su-Jung, Hahn, Seongmin, Cooper, Scott, Sun, Zejin, Jiang, Li, Yang, XianLin, Yuan, Jin, Kosoff, Rachelle, Sandusky, George, Srour, Edward F., Chernoff, Jonathan, Clapp, Wade
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409559/
https://ncbi.nlm.nih.gov/pubmed/25586960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1951
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