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Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life

During fetal development, the lung is filled with fluid that is secreted by an active Cl- transport promoting lung growth. The basolateral Na(+),K(+),2Cl(-) cotransporter (NKCC1) participates in Cl(-) secretion. The apical Cl(-) channels responsible for secretion are unknown but studies suggest an i...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Laube, Mandy, Bossmann, Miriam, Thome, Ulrich H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409322/
https://ncbi.nlm.nih.gov/pubmed/25910246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124833
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