Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice

ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Huang, LinZhang, Fan, BaoYan, Ma, Ang, Shaul, Philip W., Zhu, HaiBo
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2015
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409288/
https://ncbi.nlm.nih.gov/pubmed/25761370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054742
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