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Inhibition of ABCA1 protein degradation promotes HDL cholesterol efflux capacity and RCT and reduces atherosclerosis in mice

ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation...

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Bibliografske podrobnosti
izdano v:J Lipid Res
Main Authors: Huang, LinZhang, Fan, BaoYan, Ma, Ang, Shaul, Philip W., Zhu, HaiBo
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409288/
https://ncbi.nlm.nih.gov/pubmed/25761370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054742
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