Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver

Cholesterol homeostasis is strictly regulated through the modulation of HMG-CoA reductase (HMGCR), the rate-limiting enzyme of cholesterol synthesis. Phosphorylation of HMGCR inactivates it and dephosphorylation activates it. AMP-activated protein kinase (AMPK) is the major kinase phosphorylating th...

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Publicat a:J Lipid Res
Autors principals: Zhang, Xiujuan, Song, Yongfeng, Feng, Mei, Zhou, Xinli, Lu, Yingli, Gao, Ling, Yu, Chunxiao, Jiang, Xiuyun, Zhao, Jiajun
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409286/
https://ncbi.nlm.nih.gov/pubmed/25713102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M047654
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