Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions

Matrix metalloproteinase 13 (Mmp13, collagenase-3) plays an essential role in bone metabolism and mineral homeostasis. It is regulated by numerous factors, including BMP-2, parathyroid hormone, and 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), through transcription factors such as Runt-related tran...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Meyer, Mark B., Benkusky, Nancy A., Pike, J. Wesley
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409268/
https://ncbi.nlm.nih.gov/pubmed/25773540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648394
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