Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells

The clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 nuclease system has provided a powerful tool for genome engineering. Double strand breaks may trigger nonhomologous end joining repair, leading to frameshift mutations, or homology-directed repair using an ext...

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Autors principals: Canver, Matthew C., Bauer, Daniel E., Dass, Abhishek, Yien, Yvette Y., Chung, Jacky, Masuda, Takeshi, Maeda, Takahiro, Paw, Barry H., Orkin, Stuart H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
DNA and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118095/
https://ncbi.nlm.nih.gov/pubmed/24907273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.564625
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