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Variable Substrate Preference among Phospholipase D Toxins from Sicariid Spiders

Venoms of the sicariid spiders contain phospholipase D enzyme toxins that can cause severe dermonecrosis and even death in humans. These enzymes convert sphingolipid and lysolipid substrates to cyclic phosphates by activating a hydroxyl nucleophile present in both classes of lipid. The most medicall...

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Vydáno v:J Biol Chem
Hlavní autoři: Lajoie, Daniel M., Roberts, Sue A., Zobel-Thropp, Pamela A., Delahaye, Jared L., Bandarian, Vahe, Binford, Greta J., Cordes, Matthew H. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409260/
https://ncbi.nlm.nih.gov/pubmed/25752604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.636951
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