Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in Vivo

In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to 0.45 mol of phosphate/mol by cardiac myosin light chain kinase (cMLCK) increases Ca(2+) sensitivity of myofilament contraction necessary for normal cardiac performance. Reduction of RLC phosphorylation in c...

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Udgivet i:J Biol Chem
Main Authors: Chang, Audrey N., Battiprolu, Pavan K., Cowley, Patrick M., Chen, Guohua, Gerard, Robert D., Pinto, Jose R., Hill, Joseph A., Baker, Anthony J., Kamm, Kristine E., Stull, James T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409237/
https://ncbi.nlm.nih.gov/pubmed/25733667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642165
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