Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pH

The highly pathogenic avian influenza (AI) virus, H5N1, is a serious threat to public health worldwide. Both the currently circulating H5N1 and previously circulating AI viruses recognize avian-type receptors; however, only the H5N1 is highly infectious and virulent in humans. The mechanism(s) under...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Daidoji, Tomo, Watanabe, Yohei, Ibrahim, Madiha S., Yasugi, Mayo, Maruyama, Hisataka, Masuda, Taisuke, Arai, Fumihito, Ohba, Tomoyuki, Honda, Ayae, Ikuta, Kazuyoshi, Nakaya, Takaaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409229/
https://ncbi.nlm.nih.gov/pubmed/25673693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611327
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