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Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production

Obesity is associated with a worse breast cancer prognosis, particularly in estrogen receptor alpha (ERα) positive, postmenopausal patients. We hypothesized that this is mediated in part by an elevation in breast cancer cell cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) production...

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Gepubliceerd in:Breast Cancer Res Treat
Hoofdauteurs: Bowers, Laura W., Brenner, Andrew J., Hursting, Stephen D., Tekmal, Rajeshwar R., deGraffenried, Linda A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409140/
https://ncbi.nlm.nih.gov/pubmed/25476497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-014-3223-0
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