The methyl-CpG-binding domain (MBD) is crucial for MeCP2’s dysfunction-induced defects in adult newborn neurons

Mutations in the human X-linked gene MECP2 are responsible for most Rett syndrome (RTT) cases, predominantly within its methyl-CpG-binding domain (MBD). To examine the role of MBD in the pathogenesis of RTT, we generated two MeCP2 mutant constructs, one with a deletion of MBD (MeCP2-ΔMBD), another m...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Cell Neurosci
Egile Nagusiak: Zhao, Na, Ma, Dongliang, Leong, Wan Ying, Han, Ju, VanDongen, Antonius, Chen, Teng, Goh, Eyleen L. K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2015
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408855/
https://ncbi.nlm.nih.gov/pubmed/25964742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00158
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