Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use

Treatment of vaso-occlusive crises (VOC) or events in sickle cell disease (SCD) remains limited to symptom relief with opioids. Animal models support the effectiveness of the pan-selectin inhibitor GMI-1070 in reducing selectin-mediated cell adhesion and abrogating VOC. We studied GMI-1070 in a pros...

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Vydáno v:Blood
Hlavní autoři: Telen, Marilyn J., Wun, Ted, McCavit, Timothy L., De Castro, Laura M., Krishnamurti, Lakshmanan, Lanzkron, Sophie, Hsu, Lewis L., Smith, Wally R., Rhee, Seungshin, Magnani, John L., Thackray, Helen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2015
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408290/
https://ncbi.nlm.nih.gov/pubmed/25733584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583351
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