Evidence for a role for α6* nAChRs in L-dopa-induced dyskinesias using parkinsonian α6* nAChR gain-of-function mice

L-Dopa-induced dyskinesias (LIDs) are a serious side effect of dopamine replacement therapy for Parkinson's disease. The mechanisms that underlie LIDs are currently unclear. However, preclinical studies indicate that nicotinic acetylcholine receptors (nAChRs) play a role, suggesting that drugs...

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Bibliographic Details
Published in:Neuroscience
Main Authors: Bordia, Tanuja, McGregor, Matthew, McIntosh, J.M., Drenan, Ryan M., Quik, Maryka
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408268/
https://ncbi.nlm.nih.gov/pubmed/25813704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2015.03.040
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