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Nicotinic Receptor-Mediated Reduction in l-DOPA-Induced Dyskinesias May Occur via Desensitization

l-DOPA-induced dyskinesias in Parkinson's disease are a significant clinical problem for which few therapies are available. We recently showed that nicotine reduces l-DOPA-induced abnormal involuntary movements (AIMs) in parkinsonian animals, suggesting it may be useful for the treatment of l-D...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bordia, Tanuja, Campos, Carla, McIntosh, J. Michael, Quik, Maryka
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879940/
https://ncbi.nlm.nih.gov/pubmed/20200117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.162396
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