Distinct commensals induce interleukin-1β via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury

The microbiota stimulate inflammation, but the signaling pathways and the members of the microbiota involved remain poorly understood. We found that the microbiota induce interleukin-1β (IL-1β) release upon intestinal injury and this is mediated via the NLRP3 inflammasome. Enterobacteriaceae and in...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Seo, Sang-Uk, Kamada, Nobuhiko, Muñoz-Planillo, Raúl, Kim, Yun-Gi, Kim, Donghyun, Koizumi, Yukiko, Hasegawa, Mizuho, Himpsl, Stephanie D., Browne, Hilary P., Lawley, Trevor D., Mobley, Harry L. T., Inohara, Naohiro, Núñez, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408263/
https://ncbi.nlm.nih.gov/pubmed/25862092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.03.004
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