FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes

We recently developed a longer lasting recombinant factor VIII-Fc fusion protein, rFVIIIFc, to extend the half-life of replacement FVIII for the treatment of people with hemophilia A. In order to elucidate the biological mechanism for the elongated half-life of rFVIIIFc at a cellular level we deline...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: van der Flier, Arjan, Liu, Zhan, Tan, Siyuan, Chen, Kai, Drager, Douglas, Liu, Tongyao, Patarroyo-White, Susannah, Jiang, Haiyan, Light, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408089/
https://ncbi.nlm.nih.gov/pubmed/25905473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124930
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