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Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

Some report that adult human β-cells do not replicate, but we postulate this assumption is erroneous due a postmortem decline in replication markers such as Ki67. Our earlier report showed that Ki67-marked β-cells were rarely found in human cadaveric pancreases but were in the range of 0.2–0.5% in h...

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Опубликовано в: :Diabetes
Главные авторы: Sullivan, Brooke A., Hollister-Lock, Jennifer, Bonner-Weir, Susan, Weir, Gordon C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407864/
https://ncbi.nlm.nih.gov/pubmed/25488899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1675
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