Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes

Diabetes impedes vascular repair and causes vasoregression in the brain after stroke, but mechanisms underlying this response are still unclear. We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion (I/R) injury inactivates the p85 subunit of phosphoinositide 3-kinase...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Abdelsaid, Mohammed, Prakash, Roshini, Li, Weiguo, Coucha, Maha, Hafez, Sherif, Johnson, Maribeth H., Fagan, Susan C., Ergul, Adviye
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2015
Teme:
Pharmacology and Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407857/
https://ncbi.nlm.nih.gov/pubmed/25524911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1423
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