Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes

Diabetes impedes vascular repair and causes vasoregression in the brain after stroke, but mechanisms underlying this response are still unclear. We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion (I/R) injury inactivates the p85 subunit of phosphoinositide 3-kinase...

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Vydáno v:Diabetes
Hlavní autoři: Abdelsaid, Mohammed, Prakash, Roshini, Li, Weiguo, Coucha, Maha, Hafez, Sherif, Johnson, Maribeth H., Fagan, Susan C., Ergul, Adviye
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2015
Témata:
Pharmacology and Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407857/
https://ncbi.nlm.nih.gov/pubmed/25524911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1423
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