Inhibition of human immunodeficiency virus type 1 integrase by 3'-azido-3'-deoxythymidylate.

The effects of 3'-azido-3'-deoxythymidine (AZT) and three of its intracellular metabolites, azido- thymidine mono-, di-, and triphosphates, on the human immunodeficiency virus type 1 integrase have been determined. AZT mono-, di-, and triphosphate have an IC50 for integration between 110 a...

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Bibliographic Details
Main Authors: Mazumder, A, Cooney, D, Agbaria, R, Gupta, M, Pommier, Y
Format: Artigo
Language:Inglês
Published: 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC44078/
https://ncbi.nlm.nih.gov/pubmed/8016063
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