Refining dosing by oral gavage in the dog: A protocol to harmonise welfare

INTRODUCTION: The dog is a frequently-used, non-rodent species in the safety assessment of new chemical entities. We have a scientific and ethical obligation to ensure that the best quality of data is achieved from their use. Oral gavage is a technique frequently used to deliver a compound directly...

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Bibliographic Details
Published in:J Pharmacol Toxicol Methods
Main Authors: Hall, Laura E., Robinson, Sally, Buchanan-Smith, Hannah M.
Format: Artigo
Language:Inglês
Published: Elsevier 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407634/
https://ncbi.nlm.nih.gov/pubmed/25575806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2014.12.007
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