Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing

Botulinum neurotoxins (BoNTs) are extremely potent toxins that specifically cleave SNARE proteins in peripheral synapses, preventing neurotransmitter release. Neuronal responses to BoNT intoxication are traditionally studied by quantifying SNARE protein cleavage in vitro or monitoring physiological...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Beske, Phillip H., Scheeler, Stephen M., Adler, Michael, McNutt, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407583/
https://ncbi.nlm.nih.gov/pubmed/25954159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00159
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