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DNA repair mechanisms in cancer development and therapy

DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes and tumor suppressor genes, cells undergo malignant transformation resulting in cancerous growth. Genetic defects can predispose to...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Torgovnick, Alessandro, Schumacher, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407582/
https://ncbi.nlm.nih.gov/pubmed/25954303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00157
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